The effect of the chorionic gonadotrophin on phagocytic and oxidative activity of neutrophils and monocytes

In the course of experimental work we have investigated the effect of human chorionic gonadotrophin (hCG), coresponding to I and III pregnancy trimesters, on phagocytic and oxidative activity of neutrophils and monocytes. It was shown that hormone renders the supressive action in monocyte and neutrophil phagocytic activity. Also, the hormone supresses spontaneous oxidative activity of neutrophils, however only high dose of the hormone was shown supressive action on oxidative activity of zimozan-induced monocytes. Thus, was installed that the result of the action of hCG depends on hormonal dose and also on activation state of the cells.