Effect of combination of distant gamma-radiation and antioxidant agent on endogenous intoxication parameters under condition of experimental tumor growth

This study aims to investigate the status of oxidative damage in rats with transplantable cholangiocellular RS-1 carcinoma. We investigated the ability of derivative LBK-149 oxinicotinic acid to control oxidative damage induced by tumor and irradiation. LBK-149 at a dose of 100 mg/kg was injected i.p. or i.m. before or after irradiation. Biochemical methods were used for this investigation. The greatest therapeutic efficiency has noted been at a combination LBK-149 after irradiation, in comparison with monoirradiation and preventive injection of a LBK-149. Injection LBK-149 (100 mg/kg) in 10 day after irradiation has allowed to increase a doze of irradiation up to 5 Gy without increase of level of oxidative damage.