The influence of blood serum components being part of an agent for outer use on reparative osteo-, kerato- and dermogenesis experimentally

The aim of the work was to study the effect on bone and skin reparative regeneration of two concentrations of isolated from blood serum fraction used as part of an agent with ―Tizol‖ ointment base for outer application in 30 laboratory white mice experimentally. The animals who had closed fractures of leg bones three days before blood intake served as donors of serum components. The animals which were subjected to rib fracture were recipients of the agent. It was established that using the ointment base alone, as well as the blood plasma fraction of higher concentration, did not have a statistically significant effect on the size of cells of osteo- and chondroblastic lines, while the blood components of less concentration produce a marked osteoinducing effect. A favourable effect on kerato- and dermogenesis was noted in both experimental groups, and this effect was the most marked in the group with higher concentration of blood serum components.