Influence of conditionally ubiquitous overexpression of DNA repair genes on resistance of Drosophila melanogaster individuals to different stress factors (oxidative stress, heat shock, starvation)

The influence of conditioned ubiquitous overexpression of DNA repair genes, which are involved in damage recognition ( Hus1, mnk ), excision repair ( mei- 9, mus210, Rrp1 ) and double-strand break repair ( Brca2, Ku80, spnB, WRNexo ) on Drosophila resistance to different stress factors - oxidative stress (20 μM paraquat), heat shock (35 °C) and starvation was studied. It is shown that in most cases overexpression of DNA repair genes did not stimulate stress- resistance of Drosophila individuals. The results also demonstrate the important role of these genes in provision of stress-resistance of the whole organism.