The influence of the inflammatory mediators on the peripheral blood monocytes in the normal conditions and in endotoxicosis

It was revealed that in endotoxicosis the process of apoptosis in peripheral blood monocytes intensifies. But the number of cells dying by necrosis increases as well. The determination of the ratio of viable cells, the number of cells dying by apoptosis and necrosis, may serve as the predictor of estimation the severity of endotoxicosis, prospects for a favorable outcome and a successful treatment of the disease. Hydrogen peroxide, histamine, serotonin, however with the different proapoptotic activity, affect on the start of apoptosis program in donor's blood monocytes and in the blood monocytes of the patients with endotoxicosis.