Effect of neoadjuvant chemotherapy on the spectrum and expression profile of disregeneratory changes in the bronchial mucosa in patients with non-small cell lung cancer

Effect of neoadjuvant chemotherapy (NACT) on the character and immune phenotypes of disregeneratory processes and dysplasia in bronchial mucosa adjacent to the tumor was analyzed in 112 patients who underwent surgery for non-small cell lung cancer. Of these patients, 48 (42,8 %) received neoadjuvant paclitaxel and carboplatin chemotherapy. Tumor and tissue fragments of the removed lung at the distance of 4-5 cm from the lesion were the material for histological examination. In order to evaluate the effect of NACT on the character of diregeneratory processes, the levels of proliferative activity, apoptosis (Ki67, p53, bcl-2) and pavement epithelium differentiation (CD138) in cells of each version of disregeneratory changes were compared. It was found that NACT for non-small cell lung cancer influences no on the frequency of different types of disregeneratory changes occurring in bronchial mucosa adjacent to the tumor and on their expression profile.