Adenosine and histamine low concentration influence on muscle contraction in trachea and bronchi

Adenosine and histamine are important and biologically active molecules of the cellular structure of the lower respiratory tract. Currently, the influence of adenosine and histamine on low airways in physiologically low concentrations is not studied. The purpose of this study was to investigate the influence of low doses of adenosine (10 mkg/ml) and histamine (0,1 mkg/ml и 10 mkg/ml) on the activity of smooth muscles of the trachea and bronchi. In the course of our research, we employed both electrical stimulations of the postganglionic nerves and blockages of histamine receptors. The study revealed that adenosine leads to a much greater dilatation effect than histamine. This effect is conditioned by the broader influence of adenosine on different structures causing dilation. We concluded that he main bronchoconstriction effect is associated with the histamine and is not conditioned by the influence of adenosine or other mediators of the mast cells.