Effect of Low-molecular Pectin and Metformin on Paclitaxel Toxicity in Rats with Walker Carcinosarcoma

Автор: Kudaibergenova I., Chakeev I., Orozaliev M., Asanalieva A.

Журнал: Бюллетень науки и практики @bulletennauki

Рубрика: Медицинские науки

Статья в выпуске: 11 т.7, 2021 года.

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Recently, researchers have been particularly interested in the use of herbal agents in combination therapy of tumors with a spectrum of regulatory effects, low toxicity, and high bioavailability, as well as drugs that indirectly affect the growth and metastasis of tumor cells. The article presents the results of experiments on the study of the combined effect of metformin, low molecular weight pectin and cytostatic agent — paclitaxel on the transplantable tumor — Walker’s carcinosarcoma 256, in order to reduce the toxic effect of the chemotherapy drug. With the combined administration of pectin and paclitaxel (10 mg/kg), metformin and paclitaxel (10 mg/kg), inhibition of tumor growth was observed. On the 25th day, the death of 50% of the animals was observed in the first group, and in the remaining 50%, complete tumor regression was observed. With a single administration of paclitaxel at a single dose of 10 mg / kg of live weight, 62.5% of the animals died in the first 4 days. The combination of drugs (pectin + metformin + paclitaxel) at various single doses of paclitaxel (10, 20, and 25 mg/kg) had an antagonistic effect, showing worse results than the use of each drug with a cytostatic alone (death of animals in the period from 1 to 6 days). Thus, the experimental results demonstrated a clear toxicity reduction effect at high doses of paclitaxel in combination with pectin or metformin.

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Pectin, metformin, Walker’s carcinosarcoma 256, paclitaxel.

Короткий адрес: https://sciup.org/14121241

IDR: 14121241   |   DOI: 10.33619/2414-2948/72/18

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