Effect of platelet-rich plasma on the regeneration of damaged tissues (review)

Introduction. Platelet-rich plasma (PRP) is a universal stimulator of damaged tissue regeneration, promotes healing of damaged tissue, has anti-inflammatory, bactericidal and bacteriostatic effects, not only at the tissue level, but also at the cellular level. Main part. Platelet-rich plasma can be used in clinical practice as an alternative to antibacterial drugs (mainly beta-lactams) and hormonal drugs, which in turn can lead to significant side effects. An important advantage of using platelet-rich plasma is the fact that it does not have an oncogenic effect. With a combination of platelet-rich plasma and mesenchymal stem cells, additional stimulation of regeneration occurs, while mesenchymal stem cells adapt their secretome to the environment and their paracrine action can last for several days after transplantation. PRP is a safe stimulator of damaged tissue regeneration, an anti-inflammatory treatment. PRP is used in many areas of medicine: cosmetology, dermatology, surgery, dentistry, gynecology. Conclusion. The use of platelet-rich plasma is relevant wherever stimulation of damaged tissue regeneration and anti-inflammatory therapy are required. Also, PRP has proven itself in preclinical studies on laboratory animals.