Effect of HLDF6 peptide on splenocyte proliferation in vitro in the setting of opiate receptor agonists

Effect of bioactive HLDF6 peptide on proliferative activity of C57Bl/6 mice splenocytes in the setting of selective opiate receptors agonists was studied in cell culture. Specific agonists of m-, d- и k-receptors DAGO, DADLE and Dynorphin (1-13) were used. Opiate agonists were shown to be capable of enhancing proliferative response in mouse splenocytes during their direct interaction with cells. Data concerning combined administration of HLDF6 and opiate agonists point to the interaction between the peptide and the endogenous opiate system.