Effect of the peptide solution on the processes of rat cornea angiogenesis in experiment

Purpose: to determine the effect of a peptides solution on the processes of pathological angiogenesis in a model of post-burn neovascular albugo of the rat cornea. Material and Methods. The study was carried out at 24 rats (48 eyes). Post-burn neovascular albugo was treated after 30 days of the formation of a chemical burn of the cornea. One eye of each animal was used as a control eye, and the other was an experimental eye. In the 1st experimental group (12 animals, 12 eyes) treatment was carried out with the total fraction of the peptide drug, in 2nd group — with a fraction of the peptide drug up to 30 kDa. Instillations of the culture medium, which is used in the production of a peptide drug, were used on control eyes. The research methods included ophthalmoscopy with photoregistration, optical coherence tomography (OCT) of the anterior segment of the eye, assessment of morphological changes in the corneal tissues before and after treatment. The observation period was up to 30 days. Results. Treatment of post-burn corneal albugo with a peptide drug in the experimental groups had an antiangiogenic effect. In the control group, a albugo formed, which led to a thinning of the cornea, in which there were vessels of different functional state. Conclusion. The results obtained indicate the prospects of using a peptide solution for the treatment of post-burn neovascular corneal albugo.