Influence of different regimens of prostate cancer androgen deprivation on metabolic syndrome and sexual dysfunction

Androgen deprivation remains a golden standard therapy in advance Prostate cancer. Besides adequate suppression of the tumor growth, ADT causes temporary or even permanent sexual dysfunction along with the high risk of metabolic complications. In our prospective study we have included 56 patients with advanced forms of prostrate cancer and remained sexual activity whom were subjects to different regimens of ADT. The primary goal of our study was evaluation of the degree of metabolic complications and time to regain sexual activity using continuous and intermittent GnRH analogues therapy and sequential therapy with GnRH analogues and bicalutamide.