Influence of diabetes mellitus on the activity of metabolic enzymes and SERCA2A expression in cardiomiocytes and its relation with inotropic reactions of the myocardium of patients with coronary heart disease

The work was performed on the biopsy material of the heart with chronic coronary heart disease (CHD), and patients with CHD combined with type 2 diabetes mellitus. It was shown that the activity of succinate dehydrogenase (LDH) enzymes in the myocardium of patients with CHD was higher than in patients with combined pathology. Both groups had patients with both “high” and “low” SERCA2a protein. In addition, the inotropic myocardial response of patients in each group also divided into 2 subgroups. At the same time, the “high content” of the SERCA2a protein corresponded to the positive dynamics of the force-interval relationship, and the “low content” of the protein studied corresponded to the negative dynamics of the force-interval relationship (mechanical restitution). At the combined development of CHD and diabetes mellitus with a short duration of the disease, the positive dynamics of the force-interval relationship is more pronounced and corresponds to a higher level of SERCA2a expression than in the development of CHD only.