Influence of modern complex therapy on citokine blood profile in patients with non-alcohol steatohepatitis caused by infectious mononucleosis

The aim of this work is to evaluate the effectiveness of hepatoprotector (Phosphogliv) and immunomodulator (Cycloferon) combination on the cytokine blood profile in patients with non-alcoholic steatohepatitis (NASH) caused by infectious mononucleosis (MI). Materials and Methods. 68 patients (18-48 y.o.) with NASH caused by MI were examined. The patients were divided into two groups. The first group included 35 patients who were treated by a combination of phosphogliv and cycloferon. The patients of the second group (n=33) received the standard treatment for NASH. The serum concentration of pro- (IL-1ß, TNF-α) and anti-inflammatory (IL-4) cytokines was studied according to ELISA method; laboratory equipment was manufactured by Sanofi Diagnostics Pasteur (France). Results. It was found out that patients with NASH caused by MI demonstrated significant violations of the cytokine blood profile, mainly due to an elevated serum level of pro-inflammatory cytokines (IL-1β, TNF-α)...