Influence of steroid hormones on blood coagulation of epiphysectomized animals

As noted in previous studies, epiphysis is one of the important factors in the neurohormonal regulation of blood hemostatic potential. Steroid hormones are produced in the gonads, regulate the process of sexual differentiation and sexual reproduction in vertebrates and humans. In turn, these processes are regulated by the pituitary gonadotropins. After the effects of different doses of progesterone and testosterone on coagulation observed its acceleration, i.e. hypercoagulation. This work is part of the research on the influence of the epiphysis on coagulation in different experimental conditions. Coagulation has long attracted our attention due to the influence on the process of the epiphysis. Epiphysis receives information about the external light through the organ of sight, participates in the mechanism of the biological clock. During the daytime the synthesis of serotonin dominated in the epiphysis, but at night due to acetylation of serotonin, melatonin is produced. In the study of the epiphysis at different ages, it was found that with the onset of sexual maturation in the epiphysis occurs atrophy and calcification, i.e. epiphysis is rudimentary and does not have a vital function. In connection with this postulate, we decided to investigate the effect of progesterone and testosterone on hemocoagulation. Progesterone is a female steroid sex hormone that is produced by the corpus luteum of the ovary, placenta, small amounts of the adrenal cortex and testes. Progesterone plays an important role in sexual cycle, ensures the normal development of the pregnancy. The synthesis and secretion of progesterone regulated by luteinizing hormone and human chorionic gonadotropin. Testosterone is a male steroid hormone produced by the testes, adrenal glands, ovaries, placenta, and liver. Testosterone has secreted actively in the prenatal period, defining the sexual differentiation of the reproductive organs and the whole body. The synthesis and secretion of testosterone regulated by luteinizing and follicle stimulating hormone. Testosterone secretion is subject to seasonal and age changes. Sex hormones not only affect reproductive function, but also other systems. In this regard, we were interested in how these hormones affect blood clotting factors in intact and epiphysectomized animals. Epiphysis causes an acceleration of blood clotting factors. Progesterone and testosterone cause the acceleration of blood clotting in epiphysectomized animals The action of the progesterone and testosterone blood coagulation depends on the dose of its application. Small doses of progesterone accelerate the process of blood clotting, and small doses of testosterone, on the contrary, slows it. In epiphysectomized animals 30 minutes after applying of progesterone and testosterone thromboplastic activity of blood increases sharply. Steroid hormones in epiphysectomized animals cause hypercoagulations.