The influence of the autonomic nervous system regulation on the results of the radical surgical treatment of gastric cancer patients

In the present article 5-year survival in 108 patients radically operated apropos Т1-2N0-1М0 stage of gastric cancer with a different level of sympathetic activity (SA) are discussed. Functional activity of the autonomic nervous system (ANS) was tested by spectral analyses of heart rate variability (according by «Standards of measurement, physiological interpretation and clinical use», 1996). Two groups of patients were escaped: the patients with high level and low level of SA. It has been shown that the patients with low level of SA have best 5-year survival in comparison with the patients who has high level of SA (97,8 % and 80,9 %, p0,008) The influence of gastric cancer stage, a depth of tumour invasion, lymphoid nodule metastasis on this results were excluded. It has been shown that high level of SA is associated with decrease of quantity of lymphocytes in the peripheral blood and same functional parameters of cell immune response. So, the functional parameters of ANS and immune system influence on the results of the radical surgical treatment of gastric cancer patients and may be an additional prognosis factors.