Intraosseous and intra-articular injection of platelet-rich plasma in the treatment of osteoarthritis of the knee joint

It was performed an analysis of data in the periodicals about application possibilities of combining intraosseous and intra-articular routes of administration ofplatelet-rich plasma (PRP) - a product, which obtained from the patient’s blood - in the treatment of osteoarthritis (OA). In this work, the pathogenesis of thedisease is also considered, and the mechanisms of the action of the PRP are described (reducing the activity of the inflammatory process, chondroprotectiveeffect, stimulating the processes of migration and differentiation of cells, suppressing the catabolic effect of proteolytic enzymes), and the effectiveness ofapplication PRP depending on the route of administration. The results of clinical studies on the assessment of the potential use of the combined administrationof OTP in the treatment of osteoarthritis are showed. The study demonstrated that a combination of intra-articular and intraosseous administration of platelet-rich plasma leads to a persistent decrease in pain, an improvement in the functional state of the affected joint, and this method is most effective for mild andmoderate severity of osteoarthritis, as well as in young patients. The special advantages of this technic are the improvement of intraarticular homeostasis andthe correction of local destructive changes, minimally invasive manipulation.