Inflammation is the main trigger mechanism of acute coronary complications

The article presents modern views on the role of inflammation in atherogenesis. A review of studies examining the role of endothelial local factors, such as the accumulation of smooth muscle cells, T and B lymphocytes, macrophages, matrix metalloproteinase (MMP), and high-sensitivity C-reactive protein (CRP), was conducted. CRP and oxidized low-density lipoprotein (OLDL) are directly associated with inflammatory arterial damage in coronary artery disease (CAD). Monocytes, activated in areas of inflammation by monocyte chemoattractant protein (MCB-1) and MMP-1, play a major role in the rupture of atherosclerotic plaque, with the subsequent development of acute coronary complications. CRP and SLDL increase the synthesis of MMPs, tumor necrosis factor α (TNF-α), and granulocyte-macrophage colinear stimulating factor (GM-CSF).