Application of non-invasive methods for prostate cancer diagnostics

The objective of the paper is to assess the informative value of non-invasive diagnostic methods in the early prostate cancer detection.Materials and Methods. The authors examined 73 patients with suspected prostate cancer. They conducted a comparative analysis of methods for the early prostate cancer diagnosis, such as digital rectal exam (DRE), prostate-specific antigen (PSA), transrectal ultrasound (TRUS), compression sonoelastography (CS) and expression of the PCA3 gene in the urine.Results. The use of complex clinical, laboratory and radiotherapy methods, including DRE, PSA blood analysis, TRUS, compression sonoelastography and PCA3 expression analysis improves prostate cancer diagnosis. Using compression sonoelastography in early prostate cancer diagnosis increases sensitivity up to 71.4 %, specificity up to 94.4 %, accuracy up to 82.1 %, positive test predictive validity up to93.8 %, negative test predictive validity up to 73.9 % and improves the diagnostic test quality. In comparison with compression sonoelastography, PCA3 expression analysis is more accurate, has a greater negative test predictive validity and the best quality. The use of compression elastography in a standard research for early prostate cancer diagnosis significantly increases the diagnostic informative value. Conclusion. It was found out that the use of compression prostate sonoelastography PCA3 expression analysis improves early non-invasive diagnosis of prostate cancer.