Correction of detoxification and hemostasis-regulating lung ability in acute pancreatitis

Автор: Vlasov Aleksey Petrovich, Khudayberenova Guldzheren Dzhabaevna, Vlasova Tatyana Ivanovna, Al-Kubaysi Sheykh-Akhmed Saad, Muratova Tatyana Aleksandrovna, Myshkina Nina Alekseevna, Khachaturov Makar Yurevich

Журнал: Ульяновский медико-биологический журнал @medbio-ulsu

Рубрика: Клиническая медицина

Статья в выпуске: 2, 2021 года.

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In recent years, the study of the functional state of the lungs has become a topical issue for urgent surgery. This is due to the fact that the lungs play an important role in the regulation of the inflammatory response, and in the body balance control. The aim of the study is to establish the detoxification and hemostasis-correcting lung ability in acute pancreatitis experimentally and clinically; to determine the effectiveness of quantum metabolic therapy in correcting lung functional status. Materials and Methods. The experiments were performed on adult dogs (n=30). The animals were divided into two groups: the first group (n=15) - a pancreatitis model, the second group (n=15) - a pancreatitis model with complex treatment, including quantum irradiation and remaxol. Forty patients with acute severe pancreatitis were examined clinically. They were also divided into two groups. Patients of the first group (n=20) were treated according to clinical guidelines, whereas patients of the second group (n=20) underwent complex treatment, including quantum irradiation and remaxol. The level of toxic products in arterial and venous blood and the state of the hemostatic system were determined. Results. Having analyzed the results of the study, the authors can claim that pancreas tissue injury in acute pancreatitis results in endogenous systemic inflammation, that is manifested in dysfunctional lung disorders, namely, a decrease in lung detoxification activity and impaired hemostasis-regulating ability. Complex treatment with quantum radiation and remaxol increases lung reserves, thus, resisting trigger damage agents. It is manifested in an increase in lung detoxification ability and less hemostasis defects. Conclusion. The inclusion of quantum radiation and remaxol in the complex therapy of acute pancreatitis is pathogenetically substantiated. Such a therapy decreases dysfunctional lung events, such as an increase in lung detoxification ability and a decrease in hemostasis defects.


Acute pancreatitis, lungs, endotoxicosis, hemostasis

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IDR: 14121209   |   DOI: 10.34014/2227-1848-2021-2-25-35

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