Possibilities of influence on the systemic level of inflammation in the acute phase after prosthetic abdominal wall plasty

Objective. Despite the spread of the laparoscopic method of hernia treatment, which provides a reduction in the duration of the hospital stage, a quick and comfortable rehabilitation period, the incidence of complications is estimated at 7-12%. One of the main causes of complications is an inadequate local and general reaction of the body to foreign material. The severity of the inflammatory reaction to the implant is determined by an imbalance in the system of pro-inflammatory and anti-inflammatory cytokines, which leads to a change in reactivity in the leukocyte cell system. Taken together, these disorders lead to a deviation from the norm of cytochemical and immunocytochemical parameters. Solving the problems of treatment and prevention of hernias of the anterior abdominal wall has a significant potential for increasing the working capacity of the population and reducing the financial costs of healthcare, improving the patient’s quality of life and cosmetic effect. Material and methods. On the basis of SBIH NO «City Clinical Hospital №7 named after E.L. Berezov» of the city of Nizhny Novgorod prospectively analyzed the results of treatment of 74 patients aged 18 to 80 years, inclusive, who underwent prosthetic repair of an aponeurosis defect of an unstrapped hernia of the anterior abdominal wall with a standard polypropylene mesh implant. Patients of group I (groups of scientific control, n = 38) did not receive additional treatment. In group II (n = 36), patients from the first day after surgery received hydroxyethyldimethyldihy-dropyrimidine per os at a dose of 0.5 g 3 times a day before meals for 5-7 days. Blood sampling was performed before surgery and on days 3 and 5 after surgery. The study of the cytokine profile was performed using ELISA kits on the enzyme immunoassay analyzer "Lazurit” (Dynex, USA) by the Gemohelp laboratory (Nizhny Novgorod). Results. The level of C-reactive protein is characterized by a significant rise on the 3rd day after surgery (p function show_eabstract() { $('#eabstract1').hide(); $('#eabstract2').show(); $('#eabstract_expand').hide(); }