Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patients
Автор: Kashintsev A.A., Yanus G.A., Kokhanenko N.Yu., Moiseenko V.M., Hanevich M.D., Roman L.D., Ievleva A.G., Sokolenko A.P., Suspitsin E.N., Budovskiy A.I., Togo A.V., Volkov N.M., Fadeev R.V., Dinikin M.S., Ivanova A.K., Shostko K.G., Imyanitov E.N.
Журнал: Сибирский онкологический журнал @siboncoj
Рубрика: Лабораторные и экспериментальные исследования
Статья в выпуске: 5 (59), 2013 года.
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BRCA1 and BRCA2 may contribute in pancreatic cancer (PC) risk, however the selection criteria for BRCA1 testing are poorly defined. The analysis of Russian founder mutation BRCA1 5382insC in 150 PC patients identified 2 carriers. BRCA2 full-length sequencing of 8 DNA samples revealed 1 mutated allele (BRCA2 5197_5198delTC). All 3 carriers of BRCA1/2 mutations reported personal or familial history of BRCA-related cancers. Thus, BRCA1/2 testing is particularly
Brca1, brca2, pancreatic cancer, hereditary breast-ovarian cancer syndrome
Короткий адрес: https://sciup.org/14056364
IDR: 14056364
