Interaction of oxygen-sensing mechanisms in cells

Reactions of the human body to chronic, acute or interval hypoxic hypoxia are different and may be triggered by certain intracellular molecular mechanisms. The authors analyzed PubMed database using the keywords “intracellular oxygen sensing" to verify the assumption. In 1977-2019, almost 1000 papers were published on the issue including more than 50 reviews. For their analysis, the authors chose articles on molecular oxygen sensing Metazoan tissue cells, mainly animals. Cell responses to chronic hypoxia are determined by HIF-pool localized in the cytoplasm. Oxygen-sensing to acute hypoxia in cells is preconditioned by molecular mechanisms involving potassium channels of plasma cell membranes and associated juxtamembrane complexes. Molecular intracellular reactions to interval hypoxia are triggered by the prooxidant process activation in the mitochondria of cells. This review discusses the interactional characteristics of the three mechanisms of oxygen-sensing cells.