Effects of synthetic vitamin e derivative on the rheological properties of red blood cell membranes

Methods of the fluorescent analysis was investigated action of derivatives of vitamin E tiofan and tiofan-M on rheological properties of membranes of erythrocytes. The first formulation reduced the microviscosity of a lipid-lipid, and protein-lipid interactions. The second drug reduced microviscosity of the protein-lipid interactions, and increased in the area of a lipid-lipid interactions. Checking the effectiveness of antioxidant erythrocyte membranes showed that thiophane significantly inhibits peroxidation of membrane lipids and the formation of lipid-protein cross-links, restoring the rheological properties of red blood cells. This drug is recommended by us to prevent lipid peroxidation in persons working in Arctic conditions.