Interaction of systemic and local homeostasis disturbances in patients with chronic abacterial prostatitis III-B (experimental study)

Aim is to study, compare and identify the possible interrelations between the homeostasis disorders of the systemic (blood) and organ (in the prostate gland) levels in various experimental models of chronic abacterial prostatitis (CAP) III-B. Material and methods. In the experiment 90 random adult healthy male rats weighing 180-200 grams were used, which were divided into 4 groups: control group (n = 30) and 3 basic groups of experimental modeling (group 1 (n = 20) - animals with experimental model of CAP, group 2 (n = 20) - animals with experimental model of systemic stress, group 3 (n = 20) - animals with combined experimental model of CAP and system stress. Peripheral blood (systemic level) and tissue homogenate (organ level) in which identical homeostatic indices of cytokine metabolism (IL-8 and IL-10) and oxidative status (diene conjugates, malonic dialdehyde, catalase activity) were studied at all animals, and the parameters of the control group were taken as the conditional norm. Results. In the CAP model it was shown that the most significant shifts in the studied homeostatic parameters were observed in the homogenate of the prostate gland and to a lesser extent in the systemic blood flow (p