The interplay between the endocannabinoid system and physical activity

Aim. This comprehensive review synthesizes existing research to identify the relationship between the endocannabinoid system (ECS) and human physical activity. Materials and methods. Through a thorough examination of domestic and international research on endogenous opiates, we conducted a comparative analysis of the ECS’s role in modulating physiological responses to exercise. Results. Specifically, the initiated chain reactions of the ECS, which regulate and control all cellular processes and subsequent biological effects, modulate the excitability of circular pathways controlling motor functions. Conclusion. These findings suggest that the ECS influences the physiological response to physical exercise by balancing the responsiveness of neural circuits involved in motor control.