Dependences between activity of lipoprotein-associated phospholipase A2 and blood lipids in patients with arterial hypertension

The purpose of the study was to establish dependences associated with the content of blood lipids, levels of complications, and lipoprotein-associated phospholipase A2 activity in hypertensive patients with different temperament and versatile anxiety levels. A group of patients (n = 416) and healthy men (n = 422) (54,2 ± 1,8 years old) were divided into subgroups with different temperaments: choleric, sanguine, phlegmatic and melancholic temperaments with high and low anxiety levels. A depression of mild degree was revealed in high anxiety phlegmatic and melancholic patients. The serum activity and the mass of lipoprotein-associated phospholipase A2 was determined. The content of total cholesterol, total fractions of lipoproteins of low and very low-density, high-density lipoproteins, and triglycerides were identified. The atherogenic index was calculated together with the number of people suffering from an acute ischemic stroke and an acute myocardial infarction with low adherence to treatment. High anxiety phlegmatic and melancholic patients revealed the lowest content of high density lipoprotein and the highest level of atherogenic lipid fractions (triglycerides, total cholesterol, lipoproteins of low and very low density). It was combined with the high activity and high mass of lipoprotein-associated phospholipase A2. This condition was observed in the high percentage of patients suffering from hypertension. The ratio of patients with high anxiety of choleric and sanguine temperaments to those of high anxiety with phlegmatic and melancholic temperaments was 1 : 2.