Correlation of BDNF, TOMM40, APOE, AQP5 gene polymorphisms and efficacy of human - computer interfaces

Автор: Turovskiy Ya.A., Gureev A.P., Vitkalova I.Yu., Chumachenko A.G., Popov V.N.

Журнал: Ульяновский медико-биологический журнал @medbio-ulsu

Рубрика: Физиология

Статья в выпуске: 4, 2020 года.

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The aim of this paper is to assess the correlation of BDNF (brain derived neurotrophic factor), TOMM40 (translocase of outer mitochondrial membrane 40), APOE (apolipoprotein E), AQP5 (aquaporin 5), NFE2L2 (nuclear factor, erythroid 2 like 2), HTR2A (5-hydroxytryptamine receptor 2A), TPH2 gene polymorphisms and the efficacy of human-computer interfaces. Materials and Methods. The authors applied IT methods, namely, human-computer interfaces, and molecular genetic techniques. The following human-computer interfaces were used: brain-computer interface (BCI), electromyographic interface (EI) and respiratory interface (RI). The accuracy of all interfaces was determined by the number of correctly selected by the trial subject blocks containing the required symbol. The molecular and genetic method was based on genotyping using PCP-RFLP analysis. Statistical processing of the results was carried out. Results. It is shown that in the obtained multidimensional (up to 14 axes) space the variables reflecting the successfulness of myographic and respiratory interfaces closely correlate with the variables reflecting the failure of "brain-computer" interfaces. Moreover, the overestimation of the subjective time spent on the task is typical for failures. Conclusion. Thus, the processes under consideration are closely dependent on maturation and differentiation of neurons, on nutrient transport through mitochondrial membrane, on apolipoprotein level, and on membrane water channels. However, the mechanism of such a correlation needs further research.


Bdnf, tomm40, apoe, aqp5, genotyping, polymorphisms, neurocomputer interfaces

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IDR: 14117588   |   DOI: 10.34014/2227-1848-2020-4-110-121

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