Morbidity and mortality from uterine body cancer in the Republic of Kazakhstan over a 5-year period (2019-2024)

In Kazakhstan, uterine cancer occupies a leading place among oncological diseases of gynecological localization. Cancer of the uterine body is a malignant lesion of the endometrium lining the uterine cavity. Uterine body cancer is manifested by bloody discharge, watery whites from the genital tract, pain, acyclic or atypical uterine bleeding. Clinical recognition of uterine body cancer is carried out on the basis of gynecological examination, cytological analysis of aspirates, ultrasound, hysteroscopy with separate diagnostic curettage, histology results. Treatment of uterine body cancer is combined, including surgical (panhysterectomy), radiation, hormonal, chemotherapeutic components. Despite the development of modern diagnostic methods, the prevaidence of RTM is steadily increasing. According to the existing understandings of the pathogenesis of RTM development, 2 types of tumor process are distinguished. Treatment tactics are based on the morphological structure of the tumor, the degree of differentiation, the stage of the oncological process and concomitant somatic pathology. For the choice of treatment methods, it is also important to determine the receptors to hormones in the tumor. RTM metastasis most often leads to damage to the liver, kidneys and lungs, but there are also rarer manifestations of the metastatic process. This article describes the clinical observation of a patient treated with RTM, in whom the recurrence of the disease manifested itself in the form of a metastatic lesion of the pubic skin. According to literature, such localization is extremely rare, and every clinical situation deserves attention. The presence of receptors to steroid hormones in the tumor allowed to achieve stabilization of the oncoprocess with the help of hormone therapy.