Dependence of peripheral blood parameters in the immediate postoperative period with isolated spleen injury on the age of patients and the operation performed

The purpose of the study. Perform analysis of certain parameters of peripheral blood, hemoreology, vascular-platelet unit of hemostasis system in patients of different age groups with spleen injuries in the nearest postoperative period depending on performed surgery. Materials and methods. The work is based on an analysis of the course of the nearest postoperative period of 120 patients admitted with closed abdominal injuries, accompanied by a rupture of the spleen. Of these, 68 patients with spleen injuries made up the main group, whose age ranged from 60 to 89 years. The comparison group included 52 young and middle-aged patients. The examined patients were examined for peripheral blood, hemoreology, vascular-platelet link of the hemostasis system. Results. The presented results show that in elderly and senile patients after splenectomy, changes in peripheral blood, hemoreology, vascular-platelet units of the hemostasis system are less pronounced than after splenectomy with autoylientransplanta-tion. At the same time, in the group of young and middle-aged patients, more pronounced changes were noted after splenectomy. There has been a significant, statistically significant decrease in red blood cell count, hemoglobin count, and hematocrit count. In addition, in the near postoperative period there is an increase in blood viscosity at all shear rates. The antithrombogenic properties of the vascular endothelium are heterogeneous: against the background of a decrease in vascular endothelial thromboresistivity, there is an increase in fibrinolytic activity, accompanied, however, by a decrease in the reserves of the tissue activator plasminogen in the vascular wall and a decrease in its secretion into the bloodstream. The presented data indicate that biologically active substances are produced in the spleen tissue to facilitate the release of tissue plasminogen activators formed in the endothelium into the bloodstream, which in turn can lead to the development of intravascular thrombosis in these patients.