A dependence of reparative osteogenesis processes on the surface properties of the implants for osteosynthesis

Solubility of the implants for osteosynthesis and their effect on reparative osteogenesis have been studied in vitro and in vivo experimentally. The dynamics of bioactive (calcium phosphate) coating dissolving on titanium implants was estimated by calcium ion accumulation in sterile 0,9 % sodium chloride solution. Radioactive and tetracycline marks accumulation was investigated in fracture femurs of 26 rats in 45 days after intramedullar introduction of the implants. The results obtained have allowed to reveal a logical chain: a different technology of coating application - different parameters of the coating degradation - different dynamics of bone tissue reparative regeneration and mineralization. Thus, there is a real possibility to form a panel of individual implants for specific clinical situations on the basis of the fundamental regularities revealed.