Relationship between the transcriptional activity of СT-genes and survival in colorectal cancer patients

Introduction. High incidence and mortality rates of colorectal cancer indicate an urgent need for the use of new highly specific diagnostic and prognostic molecular markers. in this aspect, cancer testis antigens (ctas) are of particular interest. the aim of the study was to analyze the relationship between the tran-scriptional activity of ctas and survival in colorectal cancer patients with metastases (t1-4N1-2m1-2) and without metastases (t1-3N0m0). Results. the relative expression of 16 genetic loci ( MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4, MAGE-B1, MAGE-B2, GAGE-1, GAGE-3, GAGE-4, MAGE-C1, BAGE, XAGE3, NY-ESO1, SSX2, SCP1 and PRAME1 ) was determined by real-time pcR. in colorectal cancer patients having no metastases, the expression of SSX2 and PRAME1 genes was significantly higher and the expression of BAGE was significantly lower in colon tumor tissue than in normal tissue (p