Changes of microRNA in forecast of breast cancer recurrence

The objective of the study is to estimate the microRNA content in the breast tumor tissue of women with recurrent breast cancer (within 5 years after the complex treatment) and without disease recurrence.Materials and Methods. The authors examined biopsy samples of mammary malignant tumors in 156 patients. The treatment group enrolled 72 patients with tumor recurrence; the experimental group consisted of 84 patients without relapse. They also conducted a retrospective analysis of patients’ histories. All patients suffered primary-operable luminal HER2-neo negative breast cancer, and underwent complex inpatient treatment. The total malignancy score (TMS) in the groups was 14-15 points. Besides pathomor- phological studies, the microRNA content in the tumor was estimated by real-time PCR. Statistica 6 (StatSoft Inc., USA) was used for material processing.Results. Groups of women with recurrent and disease-free breast cancer demonstrated identical changes in individual correlations in Ki-67 range (6-20 %)...