Actions and effects of malignant tumor growth and chronic neurogenic pain exerted on the glutathione system in cardiac mitochondria in experimental animals

Actions and effects of malignant tumor growth and chronic neurogenic pain exerted on the glutathione system in cardiac mitochondria in experimental animals

Автор: Neskubina Irina V., Frantsiyants Elena M., Surikova Ekaterina I., Kaplieva Irina V., Trepitaki Lyubov К., Nemashkalova Lyudmila А., Pogorelova Yulia A., Shikhlyarova Alla I., Zhukova Galina V., Anistratov Pavel N., Volkova Viktoria L., Chertova Natalia А., Zhenilo Oksana Е., Cherkasova Anna А., Selezneva Olga G.

Журнал: Cardiometry @cardiometry

Рубрика: Original research

Статья в выпуске: 13, 2018 года.

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Aim The aim hereof is to study the glutathione system peculiarities in the cardiac mitochondria in experimental animals against the background of a tumor process, chronic pain and the combined effect both of chronic pain and the tumor process. Materials and methods The experiment has been carried out in female mice of the C57BL / 6 line (n = 28), aged 8 weeks, with an initial body mass of 21-22 g. The animals have been divided into the following groups: an intact group as the reference (n = 7), a test group with a reproduction of the chronic pain model (n = 7), a comparison test group (B16/F10), which covered the animals with standard subcutaneously inoculated melanoma B16/F10 (n = 7), and the main experimental group (chronic pain + B16/F10) of mice with B16/F10 melanoma inoculated 3 weeks after the chronic pain model development (n = 7). All rodents have been decapitated with a guillotine upon completion of 3 weeks of the experiment (on 21 day of the experiment). After decapitation, the animal hearts have been quickly removed with the use of coolants, and mitochondria have been isolated...

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Cardiac mitochondria, experimental melanoma в16/f10, chronic neurogenic pain, mice, glutathione system

Короткий адрес: https://sciup.org/148308849

IDR: 148308849   |   DOI: 10.12710/cardiometry.2018.13.2734

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