Cardiac amyloidosis: consensus of the Eurasian Association of Cardiologists (EAC)

Amyloidosis is a systemic disease affecting not only the cardiovascular system. The paper discusses etiology, pathogenicity, features of clinical course of two types of amyloidosis AL- and ATTR. Data from updated international protocols and recommendations for the diagnosis of amyloidosis are summarized. A brief overview of invasive and non-invasive diagnostic methods and their combinations is provided, with an analysis of the evidence base for each of the diagnostic options and tools. The article describes an adapted algorithm for sequential diagnosis and differential diagnosis of patients with suspicion of ACM, taking into account the combination of clinical manifestations and examination data. The article covers the problem of specific treatment of AL- and ATTR, as well as symptomatic therapy, both heart failure, rhythm and conduction disorders, and neurological manifestations. The document will be useful both for primary level doctors and narrow specialists: cardiologists, neurologists, hematologists and nephrologists.