Angiotensin 1-7 - a peptide that increases the resistance of the heart to ischemia and reperfusion: narrative review

Автор: Mukhomedzyanov A. V., Popov S. V., Maslov L. N., Naryzhnaya N. V., Sirotina M. A., Kurbatov B. K., Gorbunov A. S., Kilin M., Kan A., Krylatov A. V., Podoksenov Yu. K., Stepanov I. V.

Журнал: Сибирский журнал клинической и экспериментальной медицины @cardiotomsk

Рубрика: Обзоры и лекции

Статья в выпуске: 3 т.39, 2024 года.

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Background. The high mortality rate among patients with acute myocardial infarction (AMI) is an important problem of modern cardiology. In recent years, there has not been a significant decrease in mortality in AMI. Drugs used to treat AMI are not effective enough, so there is a need to develop fundamentally new drugs that can significantly increase the heart’s tolerance to ischemia/reperfusion (I/R). Angiotensin 1-7 peptide, which can increase cardiac tolerance to I/R by activating Mas receptor in myocardial tissue, could become a prototype of such drugs. The following enzymes are involved in the formation of the cardioprotective effect of angiotensin 1-7: NO-synthase, soluble guanylyl cyclase, phosphoinositide 3-kinase, extracellular signal-regulated kinases-1/2, Akt kinase and, possibly, protein kinase G. Indirect data indicate that the hypothetical end effector in the cardioprotective impact of angiotensin 1-7 could be mitochondrial or sarcolemmal ATP-sensitive K+ channel.Aim: To review 1-7 role in increasing the heart resistance to ischemia and reperfusion. The literature search was carried out in the PubMed database with queries “angiotensin 1-7 receptors”, “stress”, “angiotensin 1-7”, “mas receptor”, “cardioprotective effects of angiotensin 1-7”.

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Heart, ischemia, reperfusion, acute myocardial infarction, angiotensin 1-7, kinases, nosynthase

Короткий адрес: https://sciup.org/149146297

IDR: 149146297   |   DOI: 10.29001/2073-8552-2024-39-3-26-33

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