Antiphospholipid syndrome in a patient with myasthenia gravis: case report

Patients with myasthenia gravis have an increased risk of other autoimmune diseases compared to population without myasthenia gravis. The development of two autoimmune diseases in one patient suggests common pathogenetic mechanisms. The article presents a case report of progression of antiphospholipid syndrome in a 44‑year-old woman 12 years after onset of myasthenia gravis with an early onset and a high titer of antibodies to acetylcholine receptors, without a history of thymectomy. This woman had a good obstetric history. She was diagnosed with antiphospholipid syndrome on the basis of clinical manifestations in form of ischemic stroke, and detection of high levels of antibodies to beta-2‑glycoprotein-1 twice with an interval of 12 weeks. In the scientific literature there are limited cases of a combination of these two rare autoimmune disorders. The particularity of clinical situation is discussed in this article.