Anticonvulsant with immunomodulating properties in alcoholism therapy: experimental study

Introduction: according to modern concepts, alcoholism is a complex disturbance of the body's homeostasis with neuroimmune mechanisms in pathogenesis, which makes it possible to seek for new effective and safe pharmacological correction agents with a neuroimmunomodulating effect. Material and Methods: the study was performed on male mice (CBAxC57Bl/6)F1 with active and passive behavioral types. Animals in the state of experimental alcoholism underwent a course (10 days) of intragastric administration of the original compound m^hBHU. The exploratory behavior (EB) of animals was evaluated in the “open field” test. To assess the intensity of the immune response mice were immunized by intraperitoneal injection of sheep red blood cells. The humoral immune response was evaluated by the number of local hemolysis zones in a semi-liquid medium. The cellular immune response was evaluated by the intensity of the delayed-type hypersensitivity reaction. Statistical processing of the results was carried out using the paired Mann-Whitney test...