TNFSF11 gene rs9594738 (C>T) polymorphism associations with osteoporosis depending on postmenopausal period

The goal of the study is to examine TNFSF11 gene RS9594738 (C>T) polymorphism associations of genotypes and alleles with osteoporotic changes of L1-L4 lumbar vertebrae in women, depending on the postmenopausal period. Materials and Methods. During the study 483 postmenopausal women were examined. Osteodensitome-try of L1-L4 lumbar vertebrae was performed by dual-energy X-ray absorptiometry (DEXA). Real-time PCR was carried out to analyze TNFSF11 gene RS9594738 polymorphism. Results. We found out significant differences in detection rate of genotypes and alleles of TNFSF11 gene RS 9594738 polymorphism in healthy women, patients with L1-L4 lumbar vertebrae osteoporosis and osteopenia both in the general test group (p=0.003 and p0.05). Conclusion. The obtained data can be used for developing criteria to identify predisposition to postmenopausal osteoporosis and to increase the efficacy of therapeutic and preventive activity.