Association between HSPA1B, S100B, and TNF- gene polymorphisms and risks of chronic mercury poisoning

We examined association between HSPA1B (+1267A/G, rs1061581), TNF-α (-308G/A, rs1800629), and S100B (C/T, rs9722) gene polymorphisms and chronic mercury poisoning (CMP). PCR-RFLP analysis was used to examine a cohort consisting of 128 workers who were chronically exposed to mercury vapor; workers were distributed into two groups. The group 1 was made up of workers with long working experience who didn’t have CMP (n = 46), the group 2 included patients with long-term CMP period (n = 82). In addition, we estimated frequencies of rs1061581genotypes in 298 practically healthy men from regional sub-population (group 3). HSPA1B (+1267A/G) polymorphic variant was established to have more frequent carriage of both minor G allele (р = 0.003) and a rare GG homozygous (р = 0.005) in the group 2 against the group 1. 23.2 % patients from the group 2 turned out to have GG genotype and CMP was diagnosed in 95 % people who had it. We didn’t detect any differences in genotypes distribution among people from the examined occupational cohort (groups 1 and 2) against the group 3. GG-HSP1AB (+1267A/G) homozygous genotype was shown to be associated with CMP risks (OR = 13.57, p function show_eabstract() { $('#eabstract1').hide(); $('#eabstract2').show(); $('#eabstract_expand').hide(); }