Ассоциация полиморфных маркеров гена TCF7L2 с сахарным диабетом типа 2
Автор: Никитин Алексей Георгиевич, Потапов Виктор Андреевич, Бровкин Алексей Николаевич, Лаврикова Елена Юрьевна, Ходырев Дмитрий Сергеевич, Шамхалова Минара Шамхаловна, Сметанина Светлана Андреевна, Суплотова Людмила Александровна, Шестакова Марина Владимировна, Носиков Валерий Вячеславович, Аверьянов Александр Вячеславович
Журнал: Клиническая практика @clinpractice
Рубрика: Оригинальные исследования
Статья в выпуске: 1 (17), 2014 года.
Бесплатный доступ
С целью изучения ассоциации с сахарным диабетом типа 2 гена TCF7L2 проанализировано распределение частот аллелей и генотипов полиморфных маркеров rs7903146 и rs12255372 этого гена. В исследование вошли группы больных сахарным диабетом типа 2 и здоровых индивидов без признаков заболевания. Сравнительный анализ распределения частот аллелей и генотипов указывает на ассоциацию с этим заболеванием полиморфного маркера rs7903146 гена TCF7L2, в то время как для маркера rs12255372 не было обнаружено статистически значимой ассоциации. На основании полученных данных можно сделать вывод о том, что в русской популяции ген TCF7L2 ассоциирован с развитием СД типа 2.
Сахарный диабет типа 2, полиморфный маркер, генетическая предрасположенность
Короткий адрес: https://sciup.org/14338481
IDR: 14338481
Список литературы Ассоциация полиморфных маркеров гена TCF7L2 с сахарным диабетом типа 2
- Пузырев Валерий Павлович. Патологическая анатомия генома человека. Новосибирск: Наука, Сибирское предприятие РАН. 1997.
- Grant Richard W, Moore Allan F, Florez Jose C. Genetic architecture of type 2 diabetes: recent progress and clinical implications. Diabetes Care. 2009. 32 (6), 1107-14.
- Parikh Hemang, Lyssenko Valeriya, Groop Leif C. Prioritizing genes for followup from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus. BMC Med Genomics. 2009; 2: 72.
- Florez J C. Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? Diabetologia. 2008. 51 (7), 1100-10.
- Jin Tianru, Liu Ling. The Wntsignaling pathway effector TCF7L2 and type 2 diabetes mellitus. Mol. Endocrinol. 2008. 22 (11), 2383-92.
- Maiese Kenneth, Li Faqi, Chong Zhao Zhong, Shang Yan Chen. The Wnt signaling pathway: aging gracefully as a protectionist? Pharmacol. Ther. 2008. 118 (1), 58-81.
- Grant Struan FA, Thorleifsson Gudmar, Reynisdottir Inga, et al. Variant of transcription factor 7like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat. Genet. 2006. 38 (3), 320-323.
- Cauchi Stéphane, Meyre David, Dina Christian, et al. Transcription factor TCF7L2 genetic study in the French population: expression in human betacells and adipose tissue and strong association with type 2 diabetes. Diabetes. 2006. 55 (10), 2903-2908.
- Groves Christopher J, Zeggini Eleftheria, Minton Jayne, et al. Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes. 2006. 55 (9), 2640-44.
- Saxena Richa, Gianniny Lauren, Burtt Noël P, et al. Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes. 2006. 55 (10), 2890-95.
- Scott Laura J, Bonnycastle Lori L, Willer Cristen J, et al. Association of transcription factor 7like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample. Diabetes. 2006. 55 (9), 2649-53.
- Zhang Cuilin, Qi Lu, Hunter David J, et al. Variant of transcription factor 7like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men. Diabetes. 2006. 55 (9), 2645-48.
- Chandak G R, Janipalli C S, Bhaskar S, et al. Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia. 2007. 50 (1), 63-67.
- Marzi C, Huth C, Kolz M, et al. Variants of the transcription factor 7like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys. Horm. Metab. Res. 2007. 39 (1), 46-52.
- Bodhini Dhanasekaran, Radha Venkatesan, Dhar Monalisa, Narayani Nagarajan, Mohan Viswanathan. The rs12255372(G/T) and rs7903146 (C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians. Metab. Clin Exp. 2007; 56 (9): 1174-78.
- Horikoshi M, Hara K, Ito C, et al. A genetic variation of the transcription factor 7like 2 gene is associated with risk of type 2 diabetes in the Japanese population. Diabetologia. 2007. 50 (4), 747-51.
- Humphries Steve E, Gable David, Cooper Jackie A, et al. Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and AfroCaribbean men and women. J. Mol. Med. 2006. 84 (12), 1005-1014.
- Lewis Joshua P, Palmer Nicholette D, Hicks Pamela J, et al. Association analysis in african ameri cans of Europeanderived type 2 diabetes single nucleotide polymorphisms from wholegenome association studies. Diabetes. 2008. 57 (8), 2220-2225.
- Helgason Agnar, P
- Schäfer S A, Tschritter O, Machicao F, et al. Impaired glucagonlike peptide1induced insulin secretion in carriers of transcription factor 7like 2 (TCF7L2) gene polymorphisms. Diabetologia 2007; 50 (12): 2443-2450.
- Kirchhoff K, Machicao F, Haupt A, et al. Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia. 2008. 51 (4), 597-601.
- Chimienti Fabrice, Devergnas Séverine, Pattou François, et al. In vivo expression and functional characterization of the zinc transporter ZnT8 in glucoseinduced insulin secretion. J Cell Sci. 2006;119:4199-4206.
- Dunn Michael F. Zincligand interactions modulate assembly and stability of the insulin hexamer a review. Biometals. 2005. 18 (4), 295-303.
- Matthews DR, Hosker JP, Rudenski A S, et al. Homeostasis model assessment: insulin resistance and betacell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28 (7):412-19.
- Johns MB, PaulusThomas JE. Purification of human genomic DNA from whole blood using sodium perchlorate in place of phenol. Anal Biochem 1989; 180 (2): 276-8.
- Калькулятор для расчета статистики в исследованиях «случай-контроль» [http://genexp.ru/calculator_or.php].
- Pearson Ewan R, Donnelly Louise A, Kimber Charlotte, et al. Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study. Diabetes. 2007. 56 (8), 2178-2182.
- Lindi Virpi I, Uusitupa Matti I J, Lindström Jaana, et al. Association of the Pro12Ala polymorphism in the PPARgamma2 gene with 3year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study. Diabetes. 2002. 51 (8), 2581-86.
- Salonen Jukka T, Uimari Pekka, Aalto JuhaMatti, et al. Type 2 diabetes wholegenome association study in four populations: the DiaGen consortium. Am. J. Hum. Genet. 2007. 81 (2), 338-45.
- Freathy Rachel M, Timpson Nicholas J, Lawlor Debbie A, et al. Common variation in the FTO gene alters diabetesrelated metabolic traits to the extent expected given its effect on BMI. Diabetes. 2008. 57 (5), 1419-26.
Статья научная
