Acute phase proteins in fatal risk prediction in men aged 60 and older suffering from ischemic heart disease

Aim. To study the role of acute phase proteins for 10-year survival rate in men aged 60 and older with IHD. Materials and Methods. 167 men aged 60 and older (mean age - 76.0 ± 0.5) with confirmed IHD were under observation. The study did not include patients after revascularization and reconstructive surgery of coronary arteries. All participants were subkected to the complex assessment of clinical-functional state of the cardiovascular system and biochemical and immunologic examination. 10-year prospective study considering death records was performed. Statistical analysis was carried out using statistical programs STATISTICA 6.0 and SPSS 13.0. Results. The results of 10-year death probability analysis in men aged 60 and older with IHD have shown that risk of death is higher at the increased concentration of acute phase proteins - C-reactive protein, fibrinogen, increased concentration of beta-globulin protein fraction bearing atherogenic lipid fractions, and gamma-globulin fraction reflecting the stimulated production of antibodies participating in formation of atherogenic lipoprotein complexes - immunoglobulins G. Conclusion. 10-year death rate in men aged 60 and older with IHD is higher at the increased concentration of acute phase protein - C-reactive protein, which makes it possible to use this indicator for fatal risk stratification in men aged 60 and older with IHD.