Безопасность терапии мезенхимальными стромальными клетками

Безопасность терапии мезенхимальными стромальными клетками

Автор: Князев Олег Владимирович, Коноплянников Анатолий Георгиевич, Парфенов Асфольд Иванович, Ручкина И.Н., Чурикова Алевтина Алексеевна, Албулова Е.А., Быкова С.В., Болдырева О.Н., Фадеева Нина Александровна, Лищинская Альбина Александровна, Бондаренко Елена Юрьевна, Каграманова Анна Валерьевна

Журнал: Клиническая практика @clinpractice

Статья в выпуске: 3 (19), 2014 года.

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Имеется большое количество литературных данных, которые свидетельствуют об эффективности клеточной терапии с использованием мезенхимальных стромальных клеток (МСК), как на доклинических моделях, так и в некоторых клинических исследованиях на небольших группах больных.В настоящее время применение MСК в широкой клинической практике ограничено соображениями безопасности. Потенциальные риски связывают с их пролиферативной способностью, риском развития инфекционных осложнений, а также - с возможной иммуногенностью самих клеток.Зарубежными исследователями был проведен анализ на основе обзора литературы, по результатам которого оценивалась клиническая безопасность применения МСК. В статье представлены также результаты нашего наблюдения за пациентами с воспалительными заболеваниями кишечника (ВЗК), которые получали МСК в отделении патологии кишечника ГБУЗ МКНЦ ДЗМ. Результаты нашего исследования, а также результаты приведенного обзора, должны предоставить ученым и организаторам здравоохранения уверенность в том, что по имеющимся научным данным, инновационный метод клеточной терапии является безопасным для клинического применения.

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Безопасность клеточной терапии, мезенхимальные стромальные клетки, болезнь крона, язвенный колит

Короткий адрес: https://sciup.org/14338496

IDR: 14338496

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