Systemic inflammation biomarkers in patients with stable ischemic heart disease associated with obstructive sleep apnea syndrome

The local secretion of pro-inflammatory cytokines observed after coronary revascularization is a predictor of restenosis formation and complications of ischemic heart disease (IHD). Taking into account the pathogenetic mechanisms common with obstructive sleep apnea (OSA), a cytokine effect can be suggested. The aim of the paper was to study the activity of pro-inflammatory interleukiniв, interleukin-6 and antiinflammatory interleukin-10 in patients with a stable IHD associated with obstructive sleep apnea, against the background of antiplatelet therapy. Materials and Methods. The authors examined 90 patients with IHD associated with OSA. The level of interleukins was measured by the enzymelinked immunosorbent assay technique and an assay kit (ELISA Vector Best, Novosibirsk). In order to confirm the OSA, a cardiorespiratory monitoring device ("Cardiotechnology-04-3P (M)") was used. Statistical analysis was performed by the software package Statistica 6.0. Results. Evaluation of systemic inflammation by the level of pro-inflammatory interleukins showed normal (73 %) and elevated (27 %) levels in patients with a stable IHD...