Biotechnological program in the form of biologically active additives to support indigenous intestinal microflora

For the prevention and treatment of gastrointestinal diseases, the microbiome of a living organism is of great importance. Human health depends on the quantitative and qualitative composition of microbiota. It is shown that under the influence of factors of the internal and external environment, a change in the indigenous intestinal microflora occurs. For the correction, prevention and regulation of intestinal microbiocinosis, within the framework of the bio-technological program, a biologically active additive (BAA) has been developed, the main components of which are the biomass of bacteria Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longumus, Lumumus bumidobactus rhamnosus, Lactobacillus acidophilus, Propionibacterium arabinosum, Propionibacterium freudenreichii, as well as inulin, beta-glucan, lactulose, and other auxiliary ingredients. As substances that perform the function of coenzymes, thiamine (vitamin B1) and pyridoxine (vitamin B6) are used. The innovation of the technology lies in the features of the composition and structure of the hard gelatin capsule, which ensure the maximum preservation of biologically active components of the formulation and outgoing delivery to target cells. Established regulated quality indicators. Sanitary, hygienic, and sanitary-toxicological indicators of dietary supplements comply with the requirements of TR TS 021/2011 “On the safety of food products”. Clinical testing of the developed supplement was carried out with the involvement of volunteers who were diagnosed with intestinal microbiota disorders. Supplements were taken 1 capsule 2 times a day (in the morning 30 minutes before meals and in the evening before bedtime) in conjunction with other drugs that regulate intestinal biocinosis. After 30 days, at the end of diet therapy, microbiota recovery was noted in 90 % of cases. The technical documentation was approved for the new product, recommendations for use were developed. BAA is included in the Federal Register.