Cerulein induced acute pancreatitis in experiment

Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, which ranges from mild, self-limiting disease to a severe form that is associated with multiple organ dysfunction syndrome (MODS), high morbidity, and mortality. Unpredictable nature of the disease, heterogeneity of disease presentations, and limited access to human samples, make research on human tissues impractical and often very difficult. We tried to identify crucial events in the pathophysiology of AP, in the course of several in vivo experimental models of the AP induction. In vivo experiment was carried out on rats using the analog of cholecystokinin octapeptide - Cerulein. The rats were divided into groups, in each group there was a different dosing regimen of the drug. As a result of a series of experimental studies, it was found that the interval low-dosage induction of AP causes more severe damage of pancreas tissue than a single administration of higher doses of the test substance.