Chemical composition and pharmacological activity of plants of the Hypericum L. genus

Chemical composition and pharmacological activity of plants of the Hypericum L. genus

Автор: Jahangirova I., Zulfugarova M., Hajiyeva E., Karimova Z.

Журнал: Бюллетень науки и практики @bulletennauki

Рубрика: Биологические науки

Статья в выпуске: 1 т.9, 2023 года.

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The purpose of this work was to present the results of summarizing the literature data on the chemical composition and pharmacological activity of the Hypericum L. genus. The chemical composition of St. John’s wort (Hyperici herba) has been studied quite fully within the Eurasian area of the species; more than 80 components have been identified. The main biologically active compounds of raw materials are anthracene derivatives (hypericin), flavonoids (rutin, quercetin, hyperozoid), phenylpropanoids (chlorogenic acid) and hyperforin. The review article presents physical constants and spectroscopic ((-NMR) proton magnetic resonance, (13C NMR) 13C nuclear magnetic resonance, (-UV) ultraviolet, (-IR) infrared) interpretations of biologically active substances obtained from secondary metabolites from species belonging to genus. The results of pharmacognostic and pharmacological studies determine the feasibility of clinical trials of St. John’s wort raw materials drugs and their use in a wide therapeutic range in the complex treatment of diseases. Herba St. John’s wort is a promising source of raw materials for obtaining antibacterial, antiviral, anti-inflammatory, astringent, diuretic, antidepressant, antioxidant, anticarcinogenic, immunotropic and adaptogenic agents.

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Spectroscopy, flavonoids, hypericum

Короткий адрес: https://sciup.org/14126198

IDR: 14126198   |   DOI: 10.33619/2414-2948/86/08

Список литературы Chemical composition and pharmacological activity of plants of the Hypericum L. genus

  • Alaniya, M. D., Kemertelidze, E. P., & Komissarenko, N. F. (2002). Flavonoidy nekotorykh vidov Astragalus L. flory Gruzii. Tbilisi. (in Russian).
  • Azarova, O. V., & Galaktionova, L. P. (2012). Flavonoidy: mekhanizm protivovospalitel'nogo deistviya. Khimiya rastitel'nogo syr'ya, (4), 61-78. (in Russian).
  • Aizeman, B. E., & Derbentsova N. A. (1976). Antimicrobial preparations from Hypericum. Kiev. (in Russian).
  • Alahmad, A., Alghoraibi, I., Zein, R., Kraft, S., Dräger, G., Walter, J. G., & Scheper, T. (2022). Identification of Major Constituents of Hypericum perforatum L. Extracts in Syria by Development of a Rapid, Simple, and Reproducible HPLC-ESI-Q-TOF MS Analysis and Their Antioxidant Activities. ACS omega, 7(16), 13475-13493. https://doi.org/10.1021/acsomega.1c06335
  • Budantsev. A. L. (1996) Rastitel'nye resursy Rossii i sopredel'nykh gosudarstv: Ch. 1. Semeistva Lycopodiaceae-Ephedraceae, Ch. 2. Dopolneniya k 1-7 t. St. Petersburg. (in Russian).
  • Sartorius, N., Barrett, B., Baumana, P., Bolduin, D., & Brand, U. (2008). Antidepressantnaya terapiya i drugie metody lecheniya depressivnykh rasstroistv: Dokazatel'nyi otchet rabochei gruppy CINP. izd. V.N. Krasnov. Moscow. (in Russian).
  • Belodubrovskaya, G. A., Blinova, K. F., & Vandyshev, V. V. (2004). Lekarstvennoe rastitel'noe syr'e. Farmakognoziya. St. Petersburg. (in Russian).
  • Belitskii, G. A., Kirsanov, K. I., Lesovaya, E. A., & Yakubovskaya, M. G. (2014). Mekhanizmy antikantserogennogo deistviya flavonoidov. Uspekhi molekulyarnoi onkologii, (1), 56-68. (in Russian).
  • Betty, R. C., & Trikojus, V. M. (1943). Hypericin and a non-fluorescent photosensitive pigment from st. john's wort (Hypericum perforatum). Australian Journal of Experimental Biology & Medical Science, 21(3).
  • Brockmann, H., & Pampus, G. (1954). Die Isolierung des Pseudohypericins. Naturwissenschaften, 41(4), 86-87. https://doi.org/10.1007/BF00633872
  • Biber, A., Fischer, H., Römer, A., & Chatterjee, S. S. (1998). Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers. Pharmacopsychiatry, 31(S 1), 36-43. https://doi.org/10.1055/s-2007-979344
  • Park, B. J., Matsuta, T., Kanazawa, T., Park, C. H., Chang, K. J., & Onjo, M. (2012). Phenolic compounds from the leaves of Psidium guajava II. Quercetin and its glycosides. Chemistry of natural compounds, 48(3), 477-479. https://doi.org/10.1007/s10600-012-0280-7
  • Cirak, C., Radusiene, J., Jakstas, V., Ivanauskas, L., Yayla, F., Seyis, F., & Camas, N. (2016). Secondary metabolites of Hypericum species from the Drosanthe and Olympia sections. South African Journal of Botany, 104, 82-90. https://doi.org/10.1016/j.sajb.2015.09.022
  • D Drobizhev, M. Y., Syrkin, A. L., & Poltavskaya, M. G. (2002). Pecherskaya MB Gelarium Giperikum pri lechenii depressii v obshchesomaticheskoi seti [Gelarium Hypericum in the treatment of depression in the somatic network]. Psikhiatriya i psikhofarmakoterapiya [Psychiatry and Clinical Psychopharmacolo-gy], 4(5), 198-199.
  • Dong-Joo, K., & Young-Soo, B. (2013). Flavonols from steam bark of Acer komarovii. Khimiya Prirodnyy Soyedineniy, (1), 114-115.
  • Tatsis, E. C., Boeren, S., Exarchou, V., Troganis, A. N., Vervoort, J., & Gerothanassis, I. P. (2007). Identification of the major constituents of Hypericum perforatum by LC/SPE/NMR and/or LC/MS. Phytochemistry, 68(3), 383-393. https://doi.org/10.1016/j.phytochem.2006.11.026
  • Faizullina, R. R. (2005). Fitokhimicheskoe izuchenie zveroboya prodyryavlennogo (Hypericum perforatum L.) flory Bashkortostana i perspektivy sozdaniya novykh lekarstvennykh sredstv na ego osnove: Avtoref. … kand. farm. nauk. Ufa. (in Russian).
  • Alali, F. Q., Tawaha, K., & Gharaibeh, M. (2009). LC-MS and LC-PDA analysis of Hypericum empetrifolium and Hypericum sinaicum. Zeitschrift für Naturforschung C, 64(7-8), 476-482. https://doi.org/10.1515/znc-2009-7-802
  • Hsu, F. T., Chen, W. T., Wu, C. T., & Chung, J. G. (2020). Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF‐κB‐mediated anti‐apoptotic potential in glioblastoma. Environmental toxicology, 35(10), 1058-1069. https://doi.org/10.1002/tox.22942
  • Gerasimov, A. I. (1972). Ob effektivnosti primeneniya novoimanina pri ingalyatsii v kompleksnom lechenii tuberkuleza legkikh i tuberkuleznogo laringita. In Fitontsidy, Kiev, 225-226. (in Russian).
  • Okmen, G., & Balpınar, N. (2017). The biological activities of Hypericum perforatum L. African Journal of Traditional, Complementary and Alternative Medicines, 14(1), 213-218. https://doi.org/10.21010/ajtcam.v14i1.23
  • Gubanov, I. A., Krylova, I. L., & Tikhonova, V. L. (1976). Dikorastushchie poleznye rasteniya SSSR. Moscow. (in Russian).
  • Gritsai, A. V., & Tomakh, N. V. (2012). Primenenie ekstrakta zveroboya v kompleksnoi terapii psikhoemotsional'nykh rasstroistv u patsientov s gipertonicheskoi bolezn'yu. Mezhdunarodnyi nevrologicheskii zhurnal, (2 (48)), 202-204. (in Russian).
  • Gromova, N. M. (1952). Farmakognosticheskoe znachenie evropeiskikh vidov zveroboya Hypericum perforatum L. i H. quadrangulum L.: Avtor. … kand. farmatsevt. nauk. Moscow. (in Russian).
  • Gheorgia, A., Jonescu-Matiu, E., & Boteanu, S. (1969). Contributii la studiul uleirilor esentiale isolate din Hypericum prforatum L. si H. acutum L. Comun. bot.(RSR), 8, 119-124.
  • Haobin, H., Xudong, Z., & Yan, L. (2012). Chemical constituents of the stem bark of Acanthopanax brachypus from China. Chemistry of Natural Compounds, 48(5), 870-872. https://doi.org/10.1007/s10600-012-0405-z
  • Huck, C. W., Abel, G., Popp, M., & Bonn, G. K. (2006). Comparative analysis of naphthodianthrone and phloroglucine derivatives in St. John's Wort extracts by near infrared spectroscopy, high-performance liquid chromatography and capillary electrophoresis. Analytica Chimica Acta, 580(2), 223-230. https://doi.org/10.1016/j.aca.2006.07.062
  • Ion, V., Ielciu, I., Cârje, A. G., Muntean, D. L., Crişan, G., & Păltinean, R. (2022). Hypericum spp.—An Overview of the Extraction Methods and Analysis of Compounds. Separations, 9(1), 17. https://doi.org/10.3390/separations9010017
  • Diaz, J. G. (2022). Chemical Composition of Hypericum Coadunatum Chr. from the Canary Islands. Journal of Molecular Structure, 1248, 131447.
  • Karyagin, I. I. (1954). Flora Azerbaidzhana (Geraniaceae-Cornaceae). Baku. 249–258. (in Russian).
  • Kirilyuk, Zh. I. (1978). Eksperimental'noe obosnovanie primeneniya preparatov zveroboya i kalankhoe pri lechenii infitsirovannykh ran. Vestnik khirurgii, (4), 126. (in Russian).
  • Kabiev, O. K., & Balmukhanov, S. B. (1975). Prirodnye fenoly predstavlyayut soboi perspektivnyi klass protivoopukholevykh i radiopotentsiiruyushchikh soedinenii. Moscow. (in Russian).
  • Pravdivtseva, O. E., & Kurkin, V. A. (2011). Steriny nadzemnoi chasti zveroboya prodyryavlennogo. Khimiya rastitel'nogo syr'ya, (4), 333-334. (in Russian).
  • Khalmatov, Kh. Kh. (1979). Rasteniya Uzbekistana mochegonnogo deistviya. Tashkent.
  • Kislichenko, V. S., Burlaka, I. S., & Karpyuk, Yu. V. (2013). Flavonoidy nadzemnoi chasti Calamagrostis epigeios. Khimiya prirodnykh soedinenii, (1), 116-117. (in Russian).
  • Khusnetdinova, L. Z., Akulov, A. N., & Dubrovnaya, S. A. (2017). Izuchenie spektra biologicheski aktivnykh flavonoidov travy Hypericum perforatum L. flory Respubliki Tatarstan metodom vysokoeffektivnoi zhidkostnoi khromatografii. Khimiya rastitel'nogo syr'ya, (4), 175-179. https://doi.org/10.14258/jcprm.2017041841
  • Lomachenko, N. V., & Bashirova, R. M. (1999). Farmakologicheskie svoistva giperitsina (obzor). Itogi biologicheskikh issledovanii Bashkirskogo universiteta za 1998 god, 105-108. (in Russian).
  • Lobanova, I. V. (2001). Issledovanie i standartizatsiya sbora, nastoya i sukhogo ekstrakta «Mirfazin»: avtoref. … kand. farm. nauk. Moscow. (in Russian).
  • Samylina, I. A., & Severtsev, V. A. (2001). Lekarstvennye rasteniya gosudarstvennoi farmakopei. Moscow. (in Russian).
  • Rusalepp, L., Raal, A., Puessa, T., & Maeeorg, U. (2017). Comparison of chemical composition of Hypericum perforatum and H. maculatum in Estonia. Biochemical Systematics and Ecology, 73, 41-46. https://doi.org/10.1016/j.bse.2017.06.004
  • Makhlayuk, V. P. (1993). Lekarstvennye rasteniya v narodnoi meditsine. Saratov. (in Russian).
  • Makeev, B. A., & Leont'ev, A. I. (1994). Biologicheski aktivnoe veshchestvo s antimikrobnoi, fagotsitarnoi, mitoticheskoi i antioksidantnoi aktivnost'yu. Patent RF, №. 2008913. (in Russian).
  • Manolova, N., & Maksimova, V. (1988). Lechebni rasteniya inkhibitory na virusy.
  • Menegazzi, M., Masiello, P., & Novelli, M. (2020). Anti-tumor activity of Hypericum perforatum L. and hyperforin through modulation of inflammatory signaling, ROS generation and proton dynamics. Antioxidants, 10(1), 18. https://doi.org/10.3390/antiox10010018
  • Müller, W. E., Singer, A., & Wonnemann, M. (2001). Гиперфорин - антидепрессант с новым механизмом действия. Фармакопсихиатрия, 34 (Суп. 1), 98-102. https://doi.org/10.1055/ s-2001-15512
  • Middleton, E. (1998). Effect of plant flavonoids on immune and inflammatory cell function. Flavonoids in the living system, 175-182. https://doi.org/10.1007/978-1-4615-5335-9_13
  • Nikolaeva, V. G. (1977). Rasteniya, primenyaemye narodami SSSR pri zabolevaniyakh pecheni i zhelchevyvodyashchikh putei. Rastitel'nye resursy, 13(2), 396. (in Russian).
  • Plakhova, N. B. (1954). Sravnitel'noe deistvie dubil'nykh rastenii, proizrastayushchikh v Sibiri, na dizenteriinuyu gruppu bakterii. Farmakologiya i toksikologiya, 17(4), 39. (in Russian).
  • Pravdivtseva, O. E., & Kurkin, V. A. (2012). Issledovanie khimicheskogo sostava nadzemnoi chasti Hypericum Perforatum L. Meditsinskii al'manakh, (5), 204-206. (in Russian).
  • Ponomareva, A. G., & Poverin, D. I. (1993). Sbor lekarstvennykh trav dlya lecheniya sakharnogo diabeta “Lidiya 1, 2, 3”. Patent RF, №2000802. (in Russian).
  • Parvez, M. K., Rehman, M. T., Alam, P., Al-Dosari, M. S., Alqasoumi, S. I., & Alajmi, M. F. (2019). Plant-derived antiviral drugs as novel hepatitis B virus inhibitors: Cell culture and molecular docking study. Saudi Pharmaceutical Journal, 27(3), 389-400. https://doi.org/10.1016/j.jsps.2018.12.008
  • Seyrekoglu, F., Temiz, H., Eser, F., & Yildirim, C. (2022). Comparison of the antioxidant activities and major constituents of three Hypericum species (H. perforatum, H. scabrum and H. origanifolium) from Turkey. South African Journal of Botany, 146, 723-727. https://doi.org/10.1016/j.sajb.2021.12.012
  • Sofi, S. H., Nuraddin, S. M., Amin, Z. A., Al-Bustany, H. A., & Nadir, M. Q. (2020). Gastroprotective activity of Hypericum perforatum extract in ethanol-induced gastric mucosal injury in Wistar rats: A possible involvement of H+/K+ ATPase α inhibition. Heliyon, 6(10), e05249. https://doi.org/10.1016/j.heliyon.2020.e05249
  • Nalimova, N., & Efeykina, N. The Content of Biologically Active Substances in Hypericum Perforatum L. and the Pharmacotherapeutic Effect of Drugs Based on it.
  • Talanov, V. V., Trusov, V. V., & Filimonov, M. A. (1992). Lekarstvennye rasteniya - dlya bol'nykh sakharnym diabetom. Kazan'. (in Russian).
  • Khademian, A., Tabefam, M., Mazarei, Z., Kanani, M. R., Sepehri, H., Delphi, L., ... & Farimani, M. M. (2021). Chemical constituents and cytotoxic activity of Stachys pilifera Benth. South African Journal of Botany, 139, 226-229. (in Russian).
  • Ushkalova, A. V., & Illarionova, T. S. (2007). Effektivnost' i bezopasnost' antidepressivnykh i sedativnykh sredstv rastitel'nogo proiskhozhdeniya. Farmateka, (20), 10-14. (in Russian).
  • Vasil'eva, N. F. Vasil'chenko, E. A., & Komissarenko, L. N. (1986). Anal'geticheskii effekt flavonoidov Rhododendron luteum Sweet, Hypericum perforatum L., Lespedeza bicolor Turcz. i L. hedysaroides (Pall.) Kitag. Rastitel'nye resursy, 22(1), 12–21. (in Russian).
  • Kang, Y. X., Zhang, H. C., Wang, P., Liu, J. J., & Ma, Y. M. (2012). Chemical constituents of the leaves from Xanthoceras sorbifolia. Chemistry of Natural Compounds, 48(5), 875-876. https://doi.org/10.1007/s10600-012-0407-x
  • Zemtsova, G. N., & Shvarts, V. Ya. (1988). Effektivnost' fitoterapii v kompleksnom lechenii bol'nykh postdizenteriinym kolitom. In Konferentsiya po meditsinskoi botanike, Kiev, 353-354. (in Russian).
  • Zhokhova, E. V., Goncharov, M. Yu., & Povydysh, M. N. (2016). Farmakognoziya. Moscow. (in Russian).
  • Zaitseva, M. M. (1966). Vliyanie zveroboya na zheludochno-kishechnyi trakt. Zdravookhranenie Belarusi, (5), 23–25. (in Russian).
  • Zimina, L. N. (2011). Farmakognosticheskoe issledovanie dlya obosnovaniya sozdaniya antidepressantov na osnove zveroboya prodyryavlennogo: Avtoref. … kand. farm. nauk. Samara. (in Russian).
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