Цитокиновый статус сыворотки крови больных раком яичников с различным уровнем циркулирующих опухолевых клеток

Цитокиновый статус сыворотки крови больных раком яичников с различным уровнем циркулирующих опухолевых клеток

Автор: Генинг Снежанна Олеговна, Абакумова Татьяна Владимировна, Антонеева Инна Ивановна, Гафурбаева Дина Урхановна, Мифтахова Регина Ривкатовна, Долгова Динара Ришатовна, Песков Андрей Борисович

Журнал: Ульяновский медико-биологический журнал @medbio-ulsu

Рубрика: Клиническая медицина

Статья в выпуске: 4, 2019 года.

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Циркулирующие опухолевые клетки (ЦОК) представляют собой основу гематогенного метастазирования. В 2003 г. было продемонстрировано их существование в крови больных раком яичников (РЯ). Известно, что воспаление играет важную роль в прогрессировании опухолей. В крови ЦОК встречаются с большим количеством компонентов, в т.ч. с цитокинами, которые способны модулировать метастатический потенциал опухолевой клетки. Целью данного исследования была оценка цитокинового статуса сыворотки крови больных раком яичников с различным уровнем циркулирующих опухолевых клеток. Материалы и методы. Объектом исследования явились первичные больные с верифицированным (гистологически либо цитологически) раком яичников II-IV степеней по FIGO (n=24) до лечения. В крови пациенток определяли число циркулирующих опухолевых клеток методом проточной цитофлюориметрии и уровни IL-6, IL-17A, IL-1ft, TGF-a, IL-4, VEGF, TNF-a, HGF, IL-18, IL-10, IL-8. Обработку результатов проводили с использованием пакета программ Statistica Windows...

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Рак яичников, цитокины, циркулирующие опухолевые клетки

Короткий адрес: https://sciup.org/14116402

IDR: 14116402   |   DOI: 10.34014/2227-1848-2019-4-50-62

Список литературы Цитокиновый статус сыворотки крови больных раком яичников с различным уровнем циркулирующих опухолевых клеток

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