Clinical and epidemiological characteristics of liver damage during COVID-19 in patients with a fatal outcome
Автор: Mahto Monika Rani, Bommineni Sekar Swathy, Zakirova Gulkaiyr, Buranchieva Aisuluu
Журнал: Бюллетень науки и практики @bulletennauki
Рубрика: Медицинские науки
Статья в выпуске: 6 т.9, 2023 года.
Бесплатный доступ
It is now known that the SARS-CoV-2 virus can infect cells in the gastrointestinal tract as well as the liver. Liver dysfunction is found in 14-53% of patients with COVID-19. Scientists have found that the SARS-CoV-2 virus can directly infect liver cells and cells lining the intra- and extrahepatic bile ducts (cholangiocytes), since they contain, although in low concentrations, a special enzyme ACE-2, which serves as an entry point into cells of some coronaviruses, including SARS-CoV-2. The next stage in the development of pathology is inflammation and the formation of blood clots. With a violent reaction of the immune system, an excessive release of cytokines occurs, which aggravates the condition and, in some cases, leads to reactive hepatitis.
Coronavirus infection, alanine aminotransferase, aspartate aminotransferase, fatty liver
Короткий адрес: https://sciup.org/14127986
IDR: 14127986 | DOI: 10.33619/2414-2948/91/32
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