The effect of an immunomodulator on lung tissue in mycobacteriosis

The aim of the research was to compare morphological and histological parameters in the lung tissue of experimental animals infected with Mycobacterium scrofulaceum using a specific immunomodulator KIM-M2. Histological examination revealed that in animals of the 1st group, the alveolar structure was preserved, in the alveolocytes the nuclei were clearly visible without visible changes. The walls of the terminal bronchioles are tense, the villi are regular in shape and do not decay. A moderate proliferation of connective tissue was noted around the large bronchi. Histological examination revealed that in animals of the 2nd group, closer to the periphery of the organ, extensive emphysema is noted, the walls of the alveoli are thinned, deformed, disintegrate, the nuclei are poorly distinguishable in alveolocytes, and undergo karyopyknosis. Around the large bronchi revealed abundant growth of connective tissue and extensive accumulations of lymphoid cells. The data obtained during the experiment confirm that the immunomodulator has a pronounced immunomodulatory effect, since in the group of animals using the specific immunomodulator KIM-M2 no morphological and histological changes in lung tissues were detected, and in animals of the 2nd group infected with Mycobacterium scrofulaceum, intensive development of pathological process in the lung.